In an article recently published within the American Journal of Public Health (AJPH) data was analyzed from 485, 746 youths aged 12 to 16 years from the population-based cross-sectional Global Youth Tobacco Survey conducted in 67 countries between 2012 and 2019 and the 2019 National Youth Tobacco Survey in the United States. The global prevalence of past-30-day e-cigarette use among youths was 9.2%, ranging from 1.9% in Kazakhstan to 33.2% in Guam. Maternal smoking, paternal smoking, secondhand smoke exposure, youth cigarette smoking, and youth other tobacco use were positively associated with e-cigarette use. E-cigarette use was moderately frequent among youths aged 12 to 16 years globally. Several important factors were associated with youth e-cigarette use. These findings highlight the need for countries worldwide to develop policies to address e-cigarette use among youths.